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Updated: Nov 23, 2025
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Update on the cellular pathogenesis of lupus
Noémie Gensous1,2, Andrea Boizard-Moracchini2, Estibaliz Lazaro3
1Department of Internal Medicine and Clinical Immunology, CHU Bordeaux (Groupe Hospitalier Saint-André).
Current Opinion in Rheumatology
|January 4, 2021
Summary
Recent findings reveal new cellular players in systemic lupus erythematosus (SLE) pathogenesis. Understanding these immune system aberrations, including low-density granulocytes and specific T and B cell subsets, offers potential therapeutic targets for SLE.
Area of Science:
- Immunology
- Cellular Biology
- Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) involves complex immune system dysregulation.
- Both innate and adaptive immunity contribute to SLE initiation and progression.
Purpose of the Study:
- To review recent findings on the cellular pathogenesis of SLE.
- To highlight novel insights from the last 18 months.
Main Methods:
- Literature review focusing on recent cellular pathogenesis studies in SLE.
- Analysis of findings related to specific immune cell subsets and interactions.
Main Results:
- Increased understanding of low-density granulocytes as proinflammatory neutrophils.
- Identification of cellular sources contributing to the interferon signature in SLE.
- Elucidation of extrafollicular T-B-cell interactions and roles of atypical memory B cells, T-peripheral helper cells, and Th10 T cells.
Conclusions:
- Recent discoveries deepen the comprehension of SLE pathogenesis mechanisms.
- Novel immune dysregulation players identified offer potential therapeutic targets for SLE.
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