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Acute severe respiratory syndrome coronavirus-2 treatment overview for pediatrics

Mark E Murphy1,2, Gwendolyn Clay3, Lara Danziger-Isakov1,4

  • 1Division of Infectious Diseases.

Current Opinion in Pediatrics
|January 4, 2021
PubMed

Insights

This review examines antiviral and anti-inflammatory treatments for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections in children. Current pediatric recommendations for coronavirus disease 2019 (COVID-19) are largely based on adult study data.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Immunology

Background:

  • The severe respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has impacted global health.
  • While most children experience mild symptoms, a significant subset develops severe coronavirus disease 2019 (COVID-19).
  • Effective treatment strategies for pediatric COVID-19 are crucial.

Purpose of the Study:

  • To review current evidence on antiviral and anti-inflammatory treatments for acute SARS-CoV-2 infections in children.
  • To evaluate the applicability of adult treatment data to pediatric populations.
  • To highlight the evolving landscape of COVID-19 treatment recommendations.

Main Methods:

  • Systematic review of existing clinical trial data and published literature.
  • Analysis of therapeutic approaches, including repurposed medications and specific antivirals.
  • Assessment of immunomodulatory strategies to mitigate inflammatory damage.

Main Results:

  • Treatment recommendations for SARS-CoV-2 are continuously updated based on clinical trial outcomes.
  • Therapeutic approaches have shifted from repurposed drugs to targeted antiviral therapies.
  • Evidence for pediatric-specific treatments is limited, often extrapolating from adult studies.

Conclusions:

  • Optimal therapies for pediatric SARS-CoV-2 infections require ongoing research and commitment from the medical community.
  • Current pediatric treatment guidelines are primarily informed by adult data.
  • Continued investigation is essential to refine and establish evidence-based treatment protocols for children.
Abstract

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