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Related Experiment Video

Updated: Nov 23, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Visual Function in Eyes with Intermediate AMD with and without Retinal Pigment Abnormalities.

Marilyn E Schneck1, Lori A Lott1, Gunilla Haegerstrom-Portnoy

  • 1The Smith-Kettlewell Eye Research Institute, San Francisco, California.

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|January 4, 2021
PubMed
Summary

A simple vision test measuring sensitivity to radial deformation can identify intermediate age-related macular degeneration (AMD) at higher risk for progression. Poorer performance indicates increased risk, potentially predicting advanced AMD development.

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Area of Science:

  • Ophthalmology
  • Vision Science
  • Medical Diagnostics

Background:

  • Intermediate age-related macular degeneration (AMD) presents varying risks for progression to advanced stages.
  • Retinal pigment abnormalities in intermediate AMD are associated with a higher risk of progression compared to large drusen alone.

Purpose of the Study:

  • To evaluate if simple, clinically feasible psychophysical measures can differentiate between intermediate AMD subtypes with different progression risks.
  • To assess the utility of shape discrimination hyperacuity as a predictor of AMD progression.

Main Methods:

  • A cohort of 39 individuals with intermediate AMD underwent a battery of vision tests, including sensitivity to radial deformation.
  • Statistical analysis (ANOVA) compared vision test performance based on the presence or absence of retinal pigment abnormalities.

Main Results:

  • Sensitivity to radial deformation was significantly reduced in eyes with pigment abnormalities compared to those without.
  • This visual impairment was more pronounced in the higher-risk AMD group.

Conclusions:

  • Performance on shape discrimination tasks correlates with retinal pigmentation status in intermediate AMD.
  • Reduced sensitivity to radial deformation may serve as a predictive marker for progression to advanced AMD.