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Influence of CMTM8 polymorphisms on lung cancer susceptibility in the Chinese Han population
Jiamin Wu1, Yao Sun1, Zichao Xiong1
1Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University.
Background:
Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk.
Methods:
To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and Haploview analysis were used by calculating odds ratio (OR) and 95% confidence intervals (CIs).
Results:
Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk in codominant (adjusted OR = 1.57, 95% CI: 1.01-2.42, P = 0.044) and dominant (adjusted OR = 1.54, 95% CI: 1.01-2.36, P = 0.047) models. After sex stratification analysis, we observed that rs6771238 was related to an increased risk of lung squamous cell carcinoma, while rs6771238 was associated with an increased risk of lung adenocarcinoma. Rs9835916 was linked to increased risk of lymph node metastasis in lung cancer patients.
Conclusion:
Our study first reported that CMTM8 polymorphisms were a risk factor for lung cancer, which suggested the potential roles of CMTM8 in the development of lung cancer.
Insights
Genetic variations in CMTM8 are linked to increased lung cancer risk. This study identifies specific CMTM8 polymorphisms as potential risk factors for lung cancer development and metastasis.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Lung cancer is a leading global cause of cancer mortality.
- CMTM8, a potential tumor suppressor gene, shows reduced expression in lung cancer.
- Understanding the genetic basis of lung cancer risk is crucial for prevention and early detection.
Purpose of the Study:
- To investigate the association between CMTM8 gene polymorphisms and the risk of developing lung cancer.
- To explore the correlation between specific CMTM8 variants and clinicopathological features of lung cancer.
Main Methods:
- Genotyping of CMTM8 polymorphisms was performed using the Agena MassArray platform.
- A case-control study included 509 lung cancer patients and 506 healthy controls.
- Statistical analyses included genetic models, stratification, and linkage disequilibrium analysis.
Main Results:
- CMTM8 rs6771238 polymorphism was significantly associated with an increased risk of lung cancer.
- This variant (rs6771238) showed differential associations with lung squamous cell carcinoma and lung adenocarcinoma.
- Another variant, rs9835916, was linked to an increased risk of lymph node metastasis in lung cancer patients.
Conclusions:
- CMTM8 genetic polymorphisms represent a significant risk factor for lung cancer.
- These findings highlight the potential role of CMTM8 in lung cancer pathogenesis.
- Further research into CMTM8's function could offer novel therapeutic targets.
