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COVID-19 and neurocognitive disorders.
Elizabeta B Mukaetova-Ladinska1,2, Golo Kronenberg3,4, Ruma Raha-Chowdhury5
1Department of Neuroscience, Psychology and Behaviour, University of Leicester.
Current Opinion in Psychiatry
|January 4, 2021
Summary
COVID-19 infection can cause neurocognitive disorders due to viral inflammation and central nervous system entry. Understanding these changes aids in managing and treating cognitive impairment following the pandemic.
Area of Science:
- Neuroscience
- Virology
- Psychiatry
Background:
- COVID-19 infection presents with diverse physical and mental health issues.
- The pandemic's psychological impact is significant, yet neurocognitive changes are poorly understood.
Purpose of the Study:
- To synthesize current knowledge on SARS-CoV-2's neurobiological impact.
- To explain the rise of neurocognitive disorders post-COVID-19.
Main Methods:
- Review of viral-induced inflammation mechanisms.
- Analysis of viral entry into the central nervous system.
- Examination of altered neurotransmitter systems.
Main Results:
- COVID-19 can lead to neuroinflammation and central nervous system invasion.
- Neurotransmitter system alterations contribute to neurocognitive deficits.
- Mild and major neurocognitive disorder symptoms are observed.
Conclusions:
- COVID-19 presents a model for studying early neurocognitive impairment.
- Evidence synthesis informs management strategies.
- Novel therapeutic opportunities for post-COVID-19 cognitive impairment are discussed.
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