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Epigenetic mechanisms influencing COVID-19
Rwik Sen1, Michael Garbati1, Kevin Bryant1
1Active Motif, Incorporated, 1914 Palomar Oaks Way, Suite 150, Carlsbad, CA 92008, USA.
Genome
|January 4, 2021
Summary
Epigenetic mechanisms are crucial in COVID-19 (coronavirus disease 2019) infection, influencing viral replication and host immunity. Epigenetic factors show promise as biomarkers and therapeutic targets for COVID-19.
Area of Science:
- Molecular Biology
- Virology
- Immunology
Background:
- COVID-19 (coronavirus disease 2019) poses a significant global health challenge.
- Epigenetic mechanisms play a role in viral replication and host immune responses.
- SARS-CoV-2 proteins interact with host epigenetic enzymes.
Purpose of the Study:
- To review the major epigenetic pathways involved in COVID-19.
- To discuss the potential of epigenetic factors as biomarkers and therapeutic targets.
- To highlight ongoing clinical trials for epigenetic therapies against SARS-CoV-2.
Main Methods:
- Literature review of epigenetic mechanisms in COVID-19.
- Analysis of interactions between SARS-CoV-2 proteins and host epigenetic factors.
- Summary of current research on epigenetic biomarkers and therapies.
Main Results:
- Epigenetic modifications affect viral receptor ACE2 expression and cytokine gene expression.
- Interactions between viral proteins and epigenetic enzymes (e.g., HDACs) are identified.
- Epigenetic factors are emerging as potential COVID-19 biomarkers and therapeutic targets.
Conclusions:
- Epigenetic mechanisms are integral to the COVID-19 disease process.
- Targeting epigenetic modifiers offers a promising strategy for combating SARS-CoV-2.
- Further research and clinical trials are needed to validate epigenetic therapies.
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