Related Experiment Video

Updated: Nov 23, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.0K

The emerging role of small non-coding RNA in renal cell carcinoma

Lifeng Ding1, Minxiao Jiang1, Ruyue Wang1

  • 1Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Translational Oncology
|January 5, 2021
PubMed

Insights

Small noncoding RNAs, including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and tRNA-derived small RNAs (tsRNAs), are implicated in renal cell carcinoma. Dysregulation of these molecules offers potential for improved diagnosis and treatment.

Area of Science:

  • Molecular Biology
  • Genomics
  • Oncology

Background:

  • Noncoding RNAs are crucial genomic elements, categorized by size into small (sncRNAs) and long (lncRNAs).
  • Small noncoding RNAs, particularly microRNAs (miRNAs), are extensively studied for their roles in cancer, including renal cell carcinoma (RCC).
  • Piwi-interacting RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs) are less explored but show aberrations in RCC, suggesting novel roles in tumorigenesis.

Purpose of the Study:

  • To review the roles of three classes of small noncoding RNAs—miRNAs, piRNAs, and tsRNAs—in renal cell carcinoma.
  • To highlight the dysregulation of these small noncoding RNAs in RCC.
  • To discuss their potential for advancing diagnosis, prognosis, and therapeutic strategies for RCC.

Main Methods:

  • Literature review of studies on small noncoding RNAs in renal cell carcinoma.
  • Analysis of current research on miRNA, piRNA, and tsRNA dysregulation in RCC.
  • Synthesis of findings regarding the diagnostic, prognostic, and therapeutic potential.

Main Results:

  • MicroRNAs are well-established players in RCC, with therapeutic strategies in clinical trials.
  • PiRNAs and tsRNAs, despite technological challenges, exhibit aberrations in RCC, indicating their involvement in tumor development.
  • Dysregulated small noncoding RNAs present novel mechanisms for RCC onset and progression.

Conclusions:

  • Small noncoding RNAs, including miRNAs, piRNAs, and tsRNAs, are significantly dysregulated in renal cell carcinoma.
  • These molecules hold promise as biomarkers for diagnosis and prognosis.
  • Targeting small noncoding RNAs represents a potential therapeutic avenue for renal cell carcinoma.
Keywords:
MicroRNAPiwi-interacting RNARenal cell carcinomaSmall noncoding RNATRNA-derived small RNA

More Related Videos

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.2K
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

33.9K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.4K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.1K
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
8.3K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
71.0K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.7K
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
27.2K