Related Experiment Video

Updated: Nov 23, 2025

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.5K

D-dimer level is a useful predictor for mortality in patients with COVID-19: Analysis of 483 cases

Mamta Soni1, Ram Gopalakrishnan2, Raju Vaishya3

  • 1Department Of Haematology & Clinical Pathology, Apollo Hospitals, 21 Gream lane, Off Greams Road, Chennai, 600031, India.

Diabetes & Metabolic Syndrome
|January 5, 2021
PubMed

Insights

Elevated D-dimer levels in COVID-19 patients significantly predict mortality, with a cutoff of 2.01 μg/mL being particularly effective. This marker is also associated with diabetes mellitus and older age.

Area of Science:

  • Medical Research
  • Hematology
  • Infectious Diseases

Background:

  • COVID-19 is a multi-system disease characterized by coagulation abnormalities.
  • Elevated D-dimer levels are frequently observed in COVID-19 patients.
  • The association between D-dimer levels, mortality, and diabetes mellitus in COVID-19 requires further elucidation.

Purpose of the Study:

  • To determine the association between D-dimer levels and mortality in COVID-19 patients.
  • To establish optimal D-dimer cutoff values for predicting mortality.
  • To investigate the relationship between D-dimer levels and diabetes mellitus in COVID-19.

Main Methods:

  • Retrospective analysis of data from 483 confirmed COVID-19 patients.
  • Evaluation of D-dimer cutoff points and C-statistics using receiver operator characteristic (ROC) curves.
  • Assessment of routine tests on admission and during hospital stay.

Main Results:

  • D-dimer elevation (≥0.50 μg/mL) was present in 80.1% of hospitalized patients.
  • A D-dimer level ≥2.01 μg/mL significantly predicted mortality (P < 0.01; HR, 3.165).
  • High D-dimer values were observed in 96% of fatal cases; median levels were 6.34 μg/mL for non-survivors and 0.94 μg/mL for survivors. Diabetic patients showed significantly higher median D-dimer (1.68 μg/mL).

Conclusions:

  • D-dimer levels during hospital stay demonstrated the highest C-index for predicting in-hospital mortality in COVID-19.
  • A D-dimer value ≥2.01 μg/mL effectively predicts in-hospital mortality in COVID-19 patients.
  • Increased D-dimer levels are significantly associated with diabetes mellitus and advanced age in COVID-19 patients.
Abstract

Keywords:
CoronoavirusCovid-19D-dimerDiabetesMortality

More Related Videos

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.2K
An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

4.0K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
157
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
122
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
126
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
95
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
346
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
563