Related Experiment Video

Updated: Nov 23, 2025

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.2K

Liver-Resident Memory CD8+ T Cells: Possible Roles in Chronic HBV Infection

Ji Won Han1,2, Eui-Cheol Shin1

  • 1Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.

International Journal of Molecular Sciences
|January 5, 2021
PubMed

Insights

Developing new treatments for chronic hepatitis B virus (HBV) infection is crucial. Targeting liver tissue-resident memory CD8+ T cells offers a promising immunotherapeutic strategy for durable viral clearance.

Area of Science:

  • Immunology
  • Hepatology
  • Virology

Background:

  • Chronic hepatitis B virus (HBV) infection presents challenges in achieving a functional cure or eliminating HBV covalently closed circular DNA (cccDNA).
  • Improving HBV-specific adaptive immune responses is vital for sustained viral clearance alongside novel antiviral therapies.
  • Tissue-resident memory CD8+ T (TRM) cells are a distinct immune cell population residing in tissues, including the liver, with unique characteristics.

Purpose of the Study:

  • To review the characteristics of liver TRM cells.
  • To explore the implications of liver TRM cells in the context of chronic HBV infection.
  • To highlight liver TRM cells as a potential immunotherapeutic target.

Main Methods:

  • Literature review focusing on TRM cell biology.
  • Analysis of studies investigating TRM cells in mouse and human liver tissues.
  • Synthesis of information on the role of liver TRM cells in chronic HBV infection.

Main Results:

  • Liver TRM cells exhibit distinct properties compared to circulating T cells, influenced by the hepatic microenvironment.
  • These cells play a significant role in immune surveillance and response within the liver.
  • Their characteristics suggest a potential for therapeutic manipulation in chronic HBV.

Conclusions:

  • Liver TRM cells possess unique features relevant to chronic HBV infection.
  • Targeting liver TRM cells represents a promising immunotherapeutic avenue for achieving durable viral clearance.
  • Further research into liver TRM cell function could lead to novel treatment strategies for chronic hepatitis B.

Keywords:
chronic HBV infectionliver-resident T celltissue-resident T cell

More Related Videos

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

3.2K
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

11.8K

Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.3K
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.9K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.1K
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.4K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
80.2K