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Updated: Nov 23, 2025
07:51
Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
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Structural Aspects and Prediction of Calmodulin-Binding Proteins.
Corey Andrews1, Yiting Xu1, Michael Kirberger2
1Center for Diagnostics and Therapeutics, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
International Journal of Molecular Sciences
|January 5, 2021
Summary
Calmodulin (CaM), a calcium-binding protein, acts as a crucial second messenger. This review details CaM-binding proteins, their interaction motifs, and prediction methods for understanding calcium-regulated biological processes.
Area of Science:
- Molecular Biology
- Biochemistry
- Cell Signaling
Background:
- Calmodulin (CaM) is a vital intracellular calcium-binding protein.
- CaM functions as a ubiquitous calcium-regulated second messenger.
- CaM mediates numerous biological activities via protein and peptide interactions.
Purpose of the Study:
- To review known CaM-binding proteins and their interaction motifs.
- To discuss shared properties of effective CaM binding partners.
- To provide an overview of historical and current CaM-binding prediction methods.
Main Methods:
- Review of existing literature on CaM-binding proteins.
- Analysis of sequence and structural data for CaM interaction prediction.
- Comparison of different CaM-binding prediction algorithms.
Main Results:
- Identification of diverse CaM-binding proteins and interaction motifs.
- Characterization of properties enabling CaM binding.
- Evaluation of the efficacy and differences in CaM-binding prediction strategies.
Conclusions:
- Understanding CaM-binding proteins enhances knowledge of calcium-mediated cellular processes.
- Continued identification and classification of CaM-binding proteins will refine our comprehension of calcium signaling.
- Improved prediction methods are key to discovering novel CaM interactions.
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