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Glyoxalase System in the Progression of Skin Aging and Skin Malignancies

Silvia Yumnam1, Lalita Subedi1, Sun Yeou Kim1,2

  • 1College of Pharmacy, Gachon University, 191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea.

International Journal of Molecular Sciences
|January 5, 2021
PubMed

Insights

The glyoxalase system detoxifies harmful dicarbonyl compounds like methylglyoxal (MGO) and glyoxal (GO). This review explores its role in skin aging, cancer, and potential therapeutic targets for skin diseases.

Area of Science:

  • Biochemistry
  • Dermatology
  • Molecular Biology

Background:

  • Dicarbonyl compounds, methylglyoxal (MGO) and glyoxal (GO), arise from glucose metabolism.
  • The glyoxalase system (glyoxalase I and II) detoxifies these compounds, preventing dicarbonyl stress.
  • Dicarbonyl stress contributes to cellular dysfunction, diabetes, aging, and cancer.

Purpose of the Study:

  • To review the glyoxalase system's role in skin aging and malignancies.
  • To explore its potential in other skin conditions like psoriasis, vitiligo, and hyperpigmentation.
  • To highlight the glyoxalase system as a therapeutic target for skin cancer.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of the glyoxalase system's biochemical pathways.
  • Synthesis of current research on dicarbonyl stress in skin pathology.

Main Results:

  • The glyoxalase system is implicated in the progression of skin aging.
  • Dysregulation of the glyoxalase system contributes to skin malignancies.
  • The glyoxalase system shows potential for treating various skin abnormalities.

Conclusions:

  • The glyoxalase system plays a critical role in maintaining skin health.
  • Targeting the glyoxalase system offers a promising strategy for anticancer drug development in skin cancer.
  • Further research into the glyoxalase system could yield novel treatments for diverse skin conditions.
Keywords:
glyoxalglyoxalasemelanomamethylglyoxalskin aging

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