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[Correlation between thyroid function and glucolipid metabolism in type 1 diabetic adults].
Y P Cheng1, X L Zhou1, F Jing1
1Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University; Shandong Clinical Medical Center of Endocrinology and Metabolism; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Ji'nan 250021, China.
Zhonghua Nei Ke Za Zhi
|January 5, 2021
Summary
Thyroid function significantly impacts glucolipid metabolism in adults with type 1 diabetes. Thyroid stimulating hormone (TSH) correlates with cholesterol and triglycerides, while FT3 and FT4 influence glucose and lipid levels.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Diabetes Mellitus
Background:
- Type 1 diabetes (T1D) management requires understanding factors influencing metabolic control.
- Thyroid dysfunction is common and can affect glucose and lipid profiles.
Purpose of the Study:
- To investigate the relationship between thyroid function and glucolipid metabolism in adults with T1D.
- To identify predictors of thyroid hormones and metabolic parameters in this population.
Main Methods:
- Retrospective analysis of 230 T1D adults hospitalized between January 2008 and January 2020.
- Statistical correlation and independent predictor analyses were performed.
Main Results:
- Thyroid stimulating hormone (TSH) showed positive correlations with total cholesterol (TC), triglycerides (TG), and LDL-C.
- Free triiodothyronine (FT3) negatively correlated with fasting plasma glucose (FPG), HbA1c, TC, and LDL-C.
- Free thyroxine (FT4) negatively correlated with TC and LDL-C.
- TC predicted TSH, FT3, and FT4; FT3 and FT4 predicted HbA1c; TSH predicted TC, TG, and LDL-C.
Conclusions:
- Thyroid function is intricately linked with glucolipid metabolism in adults with T1D.
- These findings highlight the importance of monitoring thyroid function in T1D patients for optimal metabolic management.
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