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Updated: Nov 23, 2025
08:39
A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
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[The 483rd case: renal dysfunction, numbness of right hand]
1Department of Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Nei Ke Za Zhi
|January 5, 2021
Summary
A 65-year-old woman with kidney dysfunction was diagnosed with light-chain amyloidosis. Chemotherapy led to partial hematologic response and improved renal function, highlighting the importance of accurate diagnosis.
Area of Science:
- Nephrology
- Hematology
- Pathology
Background:
- Systemic atherosclerosis was initially suspected in a 65-year-old woman presenting with hand numbness and elevated creatinine.
- Kidney biopsy revealed renal arteriolar occlusion and interstitial fibrosis, mimicking atherosclerotic changes.
Observation:
- Initial treatment with statins, ACE inhibitors, beta-blockers, and aspirin did not improve renal function.
- Congo red staining identified amorphous eosinophilic deposits in renal arterioles.
- Abnormal serum free light chain (FLC) levels and ratio confirmed light-chain amyloidosis.
Findings:
- The patient received three cycles of the BCD chemotherapy regimen (bortezomib, cyclophosphamide, dexamethasone).
- A partial hematologic response was achieved.
- Serum creatinine levels decreased from baseline to 180 μmol/L.
Implications:
- Accurate diagnosis of light-chain amyloidosis is crucial for effective treatment of renal dysfunction.
- Chemotherapy can lead to significant improvement in renal function in affected patients.
- Early identification and treatment of systemic amyloidosis can prevent irreversible kidney damage.
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