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Updated: Nov 23, 2025

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Expression and Clinical Significance of ANXA1 and DICER1 in Myelodysplastic Syndromes

Wenqi Wu1, Chengyao Wan1, Qiongni Xie1

  • 1Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|January 5, 2021
PubMed

Insights

Expression of ANXA1 and DICER1 is decreased in myelodysplastic syndromes (MDS). ANXA1 may predict leukemia transformation, while DICER1 shows diagnostic significance for MDS.

Area of Science:

  • Hematology
  • Molecular Biology
  • Oncology

Background:

  • Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
  • Understanding molecular markers in MDS is crucial for diagnosis and prognosis.

Purpose of the Study:

  • To investigate the expression levels of ANXA1 and DICER1 in MDS patients.
  • To determine the clinical significance of ANXA1 and DICER1 in MDS and their correlation with disease progression and outcomes.

Main Methods:

  • A case-control study involving 49 MDS patients and 12 healthy volunteers.
  • Quantitative real-time fluorescence PCR (qRT-PCR) was used to measure ANXA1 and DICER1 expression in bone marrow.
  • Correlation analysis between gene expression and clinical parameters was performed.

Main Results:

  • ANXA1 and DICER1 expression were significantly lower in MDS patients compared to controls.
  • Down-expression of ANXA1 helped differentiate secondary acute myeloid leukemia (s-AML) from MDS.
  • DICER1 expression effectively screened MDS patients from healthy individuals.
  • ANXA1 expression negatively correlated with bone marrow blast percentage, IPSS, and WHO subtypes.

Conclusions:

  • Bone marrow ANXA1 may serve as a biomarker for predicting leukemia transformation risk in MDS.
  • DICER1 expression holds diagnostic significance for MDS.
  • These findings highlight potential roles for ANXA1 and DICER1 in MDS management.
Abstract

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