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Updated: Nov 23, 2025

Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants

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Published on: May 23, 2020

Silver-Russell Syndrome: Orthodontic Perspective.

Zahra Khalid¹, Kashif Iqbal¹, Abdullah Jan¹

¹Department of Orthodontics, Armed Forces Institute of Dentistry, Rawalpindi, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|January 5, 2021

Summary

Silver-Russell syndrome (SRS) is a rare genetic disorder causing growth deficiency and distinct facial features. This case highlights orthodontic challenges in an 11-year-old boy with SRS, focusing on craniofacial and dental issues.

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Area of Science:

Genetics and Developmental Biology
Pediatric Endocrinology
Craniofacial Medicine

Background:

Silver-Russell syndrome (SRS) is a rare genetic disorder characterized by prenatal and postnatal growth deficiency, a triangular face, and body asymmetry.
Diagnosis is primarily clinical, though chromosomal abnormalities (e.g., chromosomes 7 and 11) are identified in some cases.
SRS presents with various craniofacial and oral manifestations, impacting dental development and occlusion.

Observation:

An 11-year-old boy diagnosed with Silver-Russell syndrome presented with significant craniofacial and oral problems.
Key issues included underdeveloped jaws (micrognathia) and severe dental crowding, necessitating specialized orthodontic intervention.
The patient's presentation underscores the complex interplay between genetic growth disorders and dental health.

Findings:

The patient exhibited classic SRS features, including growth deficiency and a characteristic triangular facial morphology.
Severe dental crowding and small jaw size were primary orthodontic concerns requiring management.
Genetic analysis revealed chromosomal abnormalities, though clinical diagnosis remained paramount.

Implications:

Early and comprehensive orthodontic assessment is crucial for managing craniofacial and dental anomalies in SRS patients.
Serial extraction and subsequent orthodontic treatment can address severe crowding and improve dental function and aesthetics.
This case emphasizes the need for multidisciplinary care, integrating genetics, endocrinology, and dentistry for optimal patient outcomes in rare growth disorders.