Related Experiment Video

Updated: Nov 23, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

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Acute interstitial nephritis and PR3-ANCA following reintroduction of pembrolizumab: a case report

Matthew Mulroy1, Sanaz Ghafouri1, Anthony Sisk2

  • 1Department of Medicine, University of California, Los Angeles, CA 90095, USA.

Immunotherapy
|January 5, 2021
PubMed

Renal toxicity from immune checkpoint inhibitors (ICIs) is an increasingly recognized cause of acute kidney injury among patients with cancer. ICI-associated acute kidney injuries typically present as acute interstitial nephritis and the timing of onset is highly variable. Herein, we present a case of a patient with relapsed metastatic melanoma previously treated with pembrolizumab who developed grade 3 immune-related renal toxicity after reintroduction of the same ICI, secondary to acute interstitial nephritis with accompanying high PR3-antineutrophil cytoplasmic antibody titer. The patient improved after steroid treatment and discontinuation of pembrolizumab. This case highlights the importance of not excluding ICI-related nephrotoxicity as a possible cause of renal failure, including in those who previously tolerated ICI treatment, since it is a treatable entity.

Keywords:
ANCAacute interstitial nephritisacute kidney injuryantineutrophil cytoplasmic antibody titerimmune checkpoint inhibitorimmunoassaysimmunotherapyimmunotoxicitypembrolizumabproton pump inhibitor

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