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Updated: Nov 23, 2025
A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
Orbital schwannoma management: a case report, literature review, and potential paradigm shift
Jennifer Lopez1, Eric B Hamill1,2, Michael Burnstine1,2
1Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Purpose:
To present a case of orbital schwannoma and assess the literature on treatment modalities.
Methods:
A MEDLINE literature search for cases of orbital schwannomas was performed using the PubMed search tool using the search terms "orbital schwannoma" and "orbital neurilemmoma." Papers were included if they were peer-reviewed, published in English, discussed management, and included the search terms. Each article was rated using the scale developed by the British Centre for Evidence-Based Medicine. In addition, we present a case report of an orbital schwannoma.
Results:
A total of 428 articles were found. 102 met the criteria for inclusion. Only two articles met Level 1 evidence and 16 were important to the clinical care process. We report a case of a biopsy-proven orbital schwannoma managed conservatively with observation over a 4-year period due to risk of cosmetic disfigurement with tumor removal. There has been no change in tumor size and no associated complications during follow up.
Conclusions:
There is a paucity of data on the natural history of orbital schwannomas. Based on our review of the literature, we recommend observation for asymptomatic or minimally symptomatic orbital schwannomas with minimal growth over an extended period of time. For rapidly growing tumors or large tumors affecting key structures causing visual loss, diplopia, aesthetic disfigurement, or patient discomfort, a more aggressive approach may be necessary.
