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Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis
Shima Hadifar1,2, Abolfazl Fateh1,2, Vahid Pourbarkhordar3
1Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
BMC Infectious Diseases
|January 5, 2021
Summary
This study analyzed Mycobacterium tuberculosis (Mtb) genotypes in Iran, finding NEW1, CAS, EAI, and T as dominant strains. Understanding Mtb population structure is crucial for effective tuberculosis control.
Area of Science:
- Microbiology
- Genetics
- Epidemiology
Background:
- Understanding Mycobacterium tuberculosis (Mtb) population structure is vital for tuberculosis (TB) control, treatment, and vaccine development.
- This systematic review and meta-analysis aimed to determine the prevalence of Mtb genotypes and sublineages in Iran.
Purpose of the Study:
- To systematically review and meta-analyze the prevalence of Mycobacterium tuberculosis genotypes and sublineages circulating in Iran.
- To provide comprehensive insight into the Mtb population structure within Iran.
Main Methods:
- A comprehensive literature search was conducted across international (MEDLINE, Scopus) and Iranian databases.
- Data from 34 studies, encompassing 8329 clinical samples, were analyzed using random or fixed effect models.
- The PRISMA flow diagram guided study selection, with analysis performed using the metafor R package and MedCalc software.
Main Results:
- NEW1 (21.94%), CAS (19.21%), EAI (12.95%), and T (12.16%) were identified as the dominant Mtb genotypes in Iran.
- Genotypes with the lowest prevalence (<2%) included West African (L 5/6), Cameroon, TUR, and H37Rv.
- The Beijing genotype showed the highest pooled prevalence of multidrug-resistant strains (2.52%), followed by CAS (1.21%).
Conclusions:
- Mycobacterium tuberculosis populations in Iran exhibit significant genetic diversity.
- Further research is necessary to deepen the understanding of national Mtb population diversity and drug resistance patterns.
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