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The influence of pre-existing hypertension on coronavirus disease 2019 patients

Zhi-Yao Wei1, Rui Qiao2, Jian Chen3

  • 1Department of Cardiology, Center for Coronary Heart Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Epidemiology and Infection
|January 5, 2021
PubMed

Insights

Patients with hypertension experienced more severe Coronavirus disease 2019 (COVID-19) outcomes. This underlying condition increases the risk of severe illness, regardless of other factors, highlighting the need for focused care.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Hypertension is a prevalent comorbidity among Coronavirus disease 2019 (COVID-19) patients.
  • Understanding the impact of pre-existing conditions on COVID-19 severity is crucial for patient management.

Purpose of the Study:

  • To investigate whether hypertension is a risk factor for severe illness in hospitalized COVID-19 patients.
  • To assess the association between hypertension and COVID-19 severity, adjusting for potential confounders.

Main Methods:

  • A multi-center, retrospective cohort study.
  • Inclusion of 498 hospitalized patients with lab-confirmed COVID-19 in China.
  • Logistic regression analysis to determine the association between hypertension and severe COVID-19.

Main Results:

  • Over 16% of COVID-19 patients had pre-existing hypertension.
  • Hypertensive patients had a significantly higher incidence of severe COVID-19 (21% vs. 10%, P = 0.007).
  • The increased risk of severe illness associated with hypertension was independent of age, sex, and admission blood pressure.

Conclusions:

  • Hypertension is a significant risk factor for severe illness in COVID-19 patients.
  • COVID-19 patients with hypertension require heightened clinical attention due to increased susceptibility to severe outcomes and cardiac complications.
  • Early identification and management of hypertension in COVID-19 patients are essential for improving prognosis.

Keywords:
COVID-19SARS-CoV-2prognosis

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