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A Timeline of Onychomycosis Therapy and Future Directions

Solomon Geizhals1, Shari R Lipner2

  • 1SUNY Downstate Medical School, Brooklyn, NY.

Skinmed
|January 5, 2021
PubMed

Insights

Onychomycosis treatment has evolved from harsh methods to targeted antifungal drugs. Current research explores novel devices and medications for improved nail fungus therapies.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Onychomycosis, a common nail fungal infection, has a long history of treatment.
  • Early treatments included corrosive substances and nail avulsion.
  • Antifungal agents have become more specific since the mid-1900s.

Purpose of the Study:

  • To review the historical progression of onychomycosis treatment.
  • To outline current therapeutic options for nail fungus.
  • To highlight emerging treatment modalities.

Main Methods:

  • Literature review of historical and current onychomycosis treatments.
  • Analysis of approved systemic and topical antifungal agents.
  • Identification of novel therapeutic approaches under investigation.

Main Results:

  • Initial treatments were invasive and non-specific.
  • Systemic antifungals like terbinafine and itraconazole are current mainstays.
  • Topical agents include ciclopirox, efinaconazole, and tavaborole.
  • Newer treatments like devices and novel drug mechanisms are in development.

Conclusions:

  • Onychomycosis treatment has advanced significantly with the development of specific antifungal drugs.
  • Current therapies include oral and topical agents.
  • Future treatments aim for enhanced efficacy and novel mechanisms of action.

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