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Hanako Koguchi-Yoshioka1,2, Elena Hoffer3, Stanley Cheuk3

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Area of Science:

  • Immunology
  • Dermatology
  • Gerontology

Background:

  • Human resident memory T cells (TRM) are functionally distinct from circulating T cells.
  • Aging impacts immune cell function, particularly in circulating T cells.

Purpose of the Study:

  • To investigate the immunologic effects of aging on human skin T cells.
  • To compare skin T-cell aging with blood T-cell aging across different ethnicities.

Main Methods:

  • Assessed T-cell density, diversity, and function in skin and blood of individuals across a range of ages.
  • Analyzed epidermal CD49a+ CD8 TRM frequency and antipathogen responses.

Main Results:

  • No decline in skin T-cell density with advancing age was observed.
  • Epidermal CD49a+ CD8 TRM frequency increased in elderly individuals.
  • Skin T-cell diversity and antipathogen responses were maintained in the elderly, contrasting with declines in blood T cells.

Conclusions:

  • Skin T cells maintain density, diversity, and protective cytokine production in elderly individuals.
  • Skin resident T cells may serve as a long-lived immune reservoir, crucial for protection in older age.
  • These findings highlight the distinct aging patterns of skin-resident versus circulating T cells.