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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Updated: Nov 23, 2025

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
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Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

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[Progress in human epidermal growth factor research].

Meiyu Wu1, Jinghua Ruan1, Boxiong Zhong1

  • 1Department of Special Economic Animal Science, College of Animal Science, Zhejiang University, Hangzhou 310029, Zhejiang, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|January 5, 2021
PubMed
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Human epidermal growth factor (hEGF) plays key roles in cell regulation and tissue repair. Research highlights its impact on wound healing, gastrointestinal ulcers, and tumor pathology.

Keywords:
human epidermal growth factormechanismstumorulcerswound repair

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Human epidermal growth factor (hEGF) is a critical signaling molecule.
  • It regulates fundamental cellular processes like proliferation, differentiation, and migration.
  • hEGF's role extends to physiological and pathological conditions, particularly tissue regeneration.

Purpose of the Study:

  • To review the research progress on human epidermal growth factor (hEGF).
  • To elucidate the gene and protein structure, characteristics, mechanisms, and biological effects of hEGF.
  • To emphasize the influence of hEGF in gastrointestinal ulcer healing, skin wound repair, and tumor pathology.

Main Methods:

  • Literature review of scientific research on hEGF.
  • Analysis of hEGF gene and protein structure and function.
  • Examination of hEGF's role in various physiological and pathological contexts.

Main Results:

  • hEGF activates epidermal growth factor receptors, initiating downstream signaling pathways.
  • hEGF is synthesized and secreted by multiple human tissues.
  • The review details hEGF's significant involvement in tissue regeneration and wound healing processes.

Conclusions:

  • hEGF is a vital factor in cellular regulation and tissue homeostasis.
  • Its therapeutic potential in treating gastrointestinal ulcers and skin wounds is significant.
  • Understanding hEGF's function is crucial for advancing treatments in regenerative medicine and oncology.