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Updated: Nov 23, 2025
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Laparoscopic Anatomical Right Hemihepatectomy via the In Situ Anterior Approach
Published on: August 8, 2025
306
Intraplacental Hepatic Heterotopia.
Saman S Karimi1, Steven Garzon2
1Pathology, University of Illinois at Chicago, Chicago, Illinois, USA.
Fetal and Pediatric Pathology
|January 5, 2021
Summary
Placental hepatic heterotopia, a rare benign lesion, is linked to preterm labor. This case highlights its association with premature delivery and the importance of accurate diagnosis to differentiate it from malignancies.
Area of Science:
- Reproductive Medicine
- Pathology
- Gynecology
Background:
- Placental hepatic heterotopia is a rare, benign placental lesion of uncertain origin.
- It is hypothesized to arise from hepatocytic differentiation of yolk sac elements.
- Previous reports indicate a strong association with preterm labor.
Observation:
- A case of intraplacental hepatic heterotopia in a 27-year-old female is presented.
- The patient experienced preterm delivery at 31 weeks and 5 days gestational age.
- Histopathological analysis revealed a well-demarcated lesion with specific cellular characteristics.
Findings:
- Lesional cells expressed HepPar-1, CAM 5.2, Glypican-3, and AFP.
- Immunohistochemical markers confirmed the hepatic origin of the lesional cells.
- Differential diagnoses included benign, primary, and metastatic malignant entities.
Implications:
- Intraplacental hepatic heterotopia is associated with premature labor.
- Accurate differentiation from maternal and fetal malignancies is crucial for patient management.
- This condition underscores the importance of thorough histopathological evaluation of placental lesions.
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