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Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung
Senay Yilmaz1, Nilgun Yilmaz Demirci, Selma Metintas
1Department of Chest Disease, Eskisehir Osmangazi University Medical Faculty (Dr Yilmaz); Department of Chest Diseases, Gazi University Medical Faculty (Dr Demirci); Lung and Pleural Cancers Research and Clinical Center, Eskisehir Osmangazi University (Dr Metintas, Dr Ak, Dr Metintas), Eskisehir; Department of Chest Diseases, Necmettin Erbakan University Meram Medical Faculty, Konya (Dr Zamani); Department of Chest Diseases, Uludag University Medical Faculty, Bursa (Dr Guçlu, Dr Karadag); Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Science University (Dr Kabalak, Dr Yilmaz, Dr Kizilgoz, Dr Cengiz, Dr Ozdemirel, Dr Ozyurek, Dr Kavurgaci, Dr Erdogan); Sureyyapasa Chest Disease and Thoracic Surgery Training and Research Hospital (Dr Ozturk, Dr Kavas); Izmir Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Science University, Izmir (Dr Yilmaz, Dr Batum, Dr Komurcuoglu, Dr Alizoroglu); Department of Chest Diseases, Baskent University Medical Faculty (Dr Serifoglu, Dr Ulubay), Ankara; Department of Chest Diseases, Ondokuz Mayis University Medical Faculty, Samsun (Dr Unsal); Department of Chest Diseases, Celal Bayar University Medical Faculty, Manisa (Dr Celik); Department of Chest Diseases (Dr In); Department of Medical Oncology (Dr Aksoy), Firat University Medical Faculty, Elaziğ; Yedikule Chest Diseases and Chest Surgery Hospital (Dr Altin, Dr Gunluoglu), Health Science University, Istanbul, Turkey.
Objective:
The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations.
Methods:
Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded.
Results:
The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure.
Conclusions:
The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.
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