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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Relationships between kidney dysfunction and left ventricular diastolic dysfunction: a hospital-based retrospective
Yoshiyasu Miyajima1,2, Tadashi Toyama3,4, Mika Mori2,5
1Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.
Journal of Nephrology
|January 5, 2021
Summary
Reduced kidney function increases the risk of developing preclinical left ventricular diastolic dysfunction (LVDD). This highlights a significant association between kidney health and early-stage heart disease.
Area of Science:
- Cardiology
- Nephrology
- Echocardiography
Background:
- Preclinical left ventricular diastolic dysfunction (LVDD) is a significant risk factor for heart failure.
- Kidney dysfunction is a known risk factor for heart failure, but its link to asymptomatic LVDD is not well-established.
Purpose of the Study:
- To investigate the association between baseline kidney function and the development of LVDD.
- To assess the impact of estimated glomerular filtration rate (eGFR) on LVDD risk.
Main Methods:
- Retrospective cohort study of 1167 patients undergoing echocardiography (2006-2016).
- LVDD defined by E/e' ratio > 14.
- Analysis of time to LVDD development and annual changes in E/e' ratio using mixed effects models.
Main Results:
- During a median follow-up of 3.2 years, 19.8% of patients developed LVDD.
- Lower eGFR was significantly associated with increased LVDD risk (HR 2.57 for eGFR < 45).
- A significant trend of increasing annual E/e' ratio changes was observed with declining eGFR.
Conclusions:
- Reduced kidney function is associated with an elevated risk of developing LVDD.
- Further long-term studies are needed to confirm the link between LVDD and symptomatic heart failure in patients with kidney dysfunction.
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