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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable, self-healing mesoporous silica nanocomposite hydrogels with improved mechanical properties.

A Zengin1, J P O Castro1, P Habibovic1

  • 1Department of Instructive Biomaterials Engineering (IBE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, the Netherlands. s.vanrijt@maastrichtuniversity.nl.

Nanoscale
|January 5, 2021
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Summary

Researchers developed self-healing hydrogels using functionalized mesoporous silica nanoparticles (MSNs) as dynamic crosslinkers. These novel biomaterials exhibit enhanced mechanical strength and rapid self-healing for regenerative medicine applications.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Regenerative Medicine

Background:

  • Self-healing hydrogels are crucial for regenerative medicine but often lack mechanical strength.
  • Mesoporous silica nanoparticles (MSNs) can enhance hydrogel properties and offer functionalities like drug delivery.
  • Current methods often use nanoparticles as fillers, limiting their potential.

Purpose of the Study:

  • To develop mechanically robust and rapidly self-healing hydrogels using MSNs as dynamic crosslinkers.
  • To investigate the role of surface-functionalized MSNs in improving hydrogel properties.
  • To explore the potential of these nanocomposites for advanced biomaterial applications.

Main Methods:

  • Synthesized thiol surface-functionalized MSNs.
  • Formulated nanocomposite hydrogels by crosslinking MSNs with polyethylene glycol (PEG) via dynamic thiol-disulfide bonds.
  • Characterized mechanical properties (storage modulus) and self-healing capabilities.
  • Assessed degradation profiles in vitro.

Main Results:

  • Achieved a significant increase in storage modulus (32 ± 5 kPa) compared to pure PEG hydrogels (1.3 ± 0.3 kPa) using functionalized MSNs.
  • Demonstrated rapid self-healing capabilities in the nanocomposite hydrogels.
  • Non-surface modified MSNs resulted in a lower storage modulus increase (3.4 ± 0.7 kPa).
  • The nanocomposites exhibited slow degradation over 6 weeks in glutathione but remained stable at physiological conditions.

Conclusions:

  • Functionalized MSNs acting as dynamic crosslinkers effectively enhance hydrogel mechanical strength and self-healing.
  • This strategy offers a promising route to multifunctional self-healing biomaterials.
  • The developed nanocomposites hold potential for diverse regenerative medicine applications.