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Updated: Nov 23, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Regioselective and Redox-Neutral Cp*IrIII -Catalyzed Allylic C-H Alkynylation
Shobhan Mondal1, Tobias Pinkert1, Constantin G Daniliuc1
1Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany.
Abstract:
Herein, we report a Cp*IrIII -catalyzed highly regioselective and redox-neutral protocol for the construction of 1,4-enynes from unactivated olefins and bromoalkynes via intermolecular allylic C-H alkynylation. The developed mild reaction conditions tolerate a broad range of common functional groups, even enabling selective alkynylation of allylic C-H bonds in the presence of other prominent directing groups. Mechanistic experiments including the isolation of a catalytically active IrIII -allyl species support an intermolecular allylic C-H activation followed by an electrophilic alkynylation.
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