Related Experiment Video

Updated: Nov 22, 2025

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions
07:21

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

Published on: June 6, 2025

525

A cross-talk between gut microbiome, salt and hypertension

Salma Naqvi1, Turky Omar Asar2, Vikas Kumar3

  • 1Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 5, 2021
PubMed

Insights

Gut microbiota influences hypertension risk. Dietary salt, gut microbes, and cardiovascular health are interconnected. Interventions targeting gut microbiome may prevent hypertension complications.

Area of Science:

  • Cardiovascular Physiology
  • Microbiome Research
  • Nutritional Science

Background:

  • Cardiac disorders are a leading cause of global mortality.
  • Hypertensive patients face elevated cardiovascular disease risk, even with medication.
  • Gut microbiome alterations are increasingly linked to cardiovascular physiology.

Purpose of the Study:

  • To explore the role of host gut-microbiota in cardiovascular disorders, particularly hypertension.
  • To investigate the connection between dietary salt, hypertension, and gut microbiome.
  • To identify dietary interventions for managing microbiota and preventing cardiovascular complications.

Main Methods:

  • Review of experimental evidence from animal and human studies.
  • Analysis of gut microbiome products: short-chain fatty acids (SCFAs) and Trimethyl Amine -N-Oxide (TMAO).
  • Examination of the relationship between dietary salt, hypertension, and gut microbial activity.

Main Results:

  • Gut microbiota products, SCFAs and TMAO, significantly impact blood pressure regulation and cardiovascular disease pathogenesis.
  • A direct link is established between dietary salt intake, hypertension, and gut microbiome composition.
  • Specific dietary interventions can modulate gut microbiota to mitigate cardiovascular risks.

Conclusions:

  • The gut microbiome plays a critical role in hypertension and cardiovascular health.
  • Understanding the gut microbiome offers novel therapeutic targets for hypertension prevention.
  • Restoring gut microbiome homeostasis presents a promising strategy for managing cardiovascular complications.

Keywords:
Cardiovascular diseaseGut microbiotaHypertensionSaltTMAO

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