Related Experiment Video
Updated: Nov 22, 2025
12:19
Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
1.6K
The Microbiome and Its Implications in Cancer Immunotherapy
1Department of Biochemistry, Faculty of Sciences, Cancer and Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Molecules (Basel, Switzerland)
|January 6, 2021
Summary
Cancer progression is linked to microbes, influencing treatments like immunotherapy. Understanding these microbes is crucial for developing new cancer diagnostics and therapies.
Area of Science:
- Oncology
- Microbiology
- Immunology
Background:
- Cancer is a leading global cause of death, with ~18 million annual fatalities.
- Established therapies include radiotherapy, chemotherapy, and immunotherapy.
- Emerging research highlights the significant role of microbes in cancer development and regulation.
Purpose of the Study:
- To review the association between various microbes and different cancer types.
- To explore the impact of microbes on cancer immunotherapeutic responses.
- To discuss the physiological roles and potential therapeutic applications of prebiotics and postbiotics in cancer.
Main Methods:
- Literature review focusing on studies investigating the microbiome-cancer axis.
- Analysis of research on microbial influence on cancer progression and immune response.
- Synthesis of data regarding microbial metabolites and their physiological effects.
Main Results:
- Microbes are implicated in both promoting and suppressing cancer development.
- Microbial activity can modulate the effectiveness of cancer immunotherapies.
- Specific microbes and their metabolites influence host physiological responses relevant to cancer.
Conclusions:
- A deeper understanding of the microbiome-cancer relationship is essential for advancing cancer treatment.
- Identifying cancer-associated microbes may lead to novel diagnostic and therapeutic strategies.
- Targeting the microbiome through prebiotics and postbiotics shows promise for cancer management.
Keywords:
CTLA-4cancer progression and microbesimmuno-oncologyimmunotherapymicrobiomephysiological responsesMore Related Videos
Related Concept Videos
01:27Tumor Immunotherapy
876
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
876
02:17The Tumor Microenvironment
7.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.3K
01:30Cancer Vaccines
628
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
628
01:29Microorganisms in Medicine and Therapeutics
676
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
676
01:19Psychoneuroimmunology: Diabetes and Cancer
144
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
144
02:53Adaptive Mechanisms in Cancer Cells
6.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.2K