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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
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Epigenetics of Aging and Aging-Associated Diseases
Dominik Saul1,2, Robyn Laura Kosinsky3
1Kogod Center on Aging and Division of Endocrinology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
International Journal of Molecular Sciences
|January 6, 2021
Summary
Aging involves epigenetic deregulation, affecting cellular processes and contributing to age-related diseases like cancer and neurodegeneration. This review explores these epigenetic changes across species and their impact on human health.
Area of Science:
- Gerontology
- Epigenetics
- Molecular Biology
Background:
- Aging is a complex process involving physiological decline.
- Epigenetic deregulation is recognized as a key hallmark of aging.
- Altered epigenetic events are observed across various species during aging.
Purpose of the Study:
- To review epigenetic mechanisms underlying aging processes.
- To describe how epigenetic deregulation contributes to aging-related diseases.
- To provide insights into the role of epigenetics in species-spanning aging.
Main Methods:
- Literature review of epigenetic changes during aging.
- Analysis of epigenetic alterations in different species.
- Correlation of epigenetic deregulation with human pathologies.
Main Results:
- Accumulation of histone variants and changes in chromatin accessibility are linked to aging.
- Loss of histones, heterochromatin, and aberrant histone modifications are observed.
- Deregulated microRNA (miRNA) expression/activity contributes to aging.
- Epigenetic changes affect cellular processes, leading to diseases such as cancer, diabetes, osteoporosis, and neurodegenerative disorders.
Conclusions:
- Epigenetic deregulation is a fundamental aspect of aging.
- Understanding these mechanisms is crucial for addressing age-related diseases.
- Epigenetic insights offer potential therapeutic targets for aging and associated pathologies.
Keywords:
CDKN2Aagingaging-associated diseasesdiabetesepigeneticsgene expressionhistone modificationshistonesosteoporosissarcopeniaMore Related Videos
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