Related Experiment Video
Updated: Nov 22, 2025
A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
The Association between Dynamic Changes in Serum Presepsin Levels and Mortality in Immunocompromised Patients with
Jongmin Lee1, Seohyun Kim1, Kyung Hoon Kim2
1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Insights
Dynamic changes in presepsin levels, a sepsis biomarker, are linked to mortality in critically ill, immunocompromised patients. Monitoring presepsin trends offers insights into sepsis outcomes.
Area of Science:
- Biochemistry
- Immunology
- Critical Care Medicine
Background:
- Presepsin, a soluble CD14 subtype, elevates in sepsis patients.
- Sepsis poses significant risks, particularly in immunocompromised individuals.
- Understanding sepsis biomarkers in vulnerable populations is crucial.
Purpose of the Study:
- To investigate the role of dynamic changes in serum presepsin levels.
- To assess presepsin's diagnostic and prognostic value in critically ill, immunocompromised sepsis patients.
- To correlate presepsin level changes with in-hospital mortality.
Main Methods:
- Prospective cohort study of 119 adult ICU patients.
- Serum presepsin measured on day 1 and day 3 post-ICU admission.
- In-hospital mortality as the primary outcome; multivariate analysis performed.
Main Results:
- Day 1 presepsin levels were higher in septic immunocompromised patients (AUC 0.87).
- Day 3 presepsin levels were higher in non-survivors.
- Increased presepsin from day 1 to day 3 (ΔPresepsin+) independently predicted mortality.
Conclusions:
- Dynamic changes in presepsin levels are associated with in-hospital mortality in sepsis.
- Presepsin shows diagnostic utility comparable to procalcitonin in immunocompromised patients.
- Monitoring presepsin kinetics may improve risk stratification in immunocompromised sepsis patients.
Abstract:
Presepsin is a subtype of soluble CD14 that is increased in the blood of septic patients. We investigated the role of dynamic changes in serum presepsin levels in critically ill, immunocompromised patients with sepsis. This is a prospective cohort study that included 119 adult patients admitted to the intensive care unit (ICU). Presepsin level was measured on day 1 and day 3 after ICU admission. The primary outcome was in-hospital mortality. In immunocompromised patients, presepsin levels on day 1 were higher in patients with sepsis than those in patients without sepsis. The area under the curve (AUC) of presepsin for diagnosing sepsis in immunocompromised patients was 0.87, which was comparable with that of procalcitonin (AUC, 0.892). Presepsin levels on day 3 were higher in patients who died in the hospital than in those who survived. In immunocompromised patients who died in the hospital, presepsin levels on day 3 were significantly higher than those on day 1. In the multivariate analysis, ΔPresepsin+ alone was independently correlated with in-hospital mortality in immunocompromised patients. These findings suggest that dynamic changes in presepsin levels between day 1 and day 3 are associated with in-hospital mortality in patients with sepsis, especially in immunocompromised patients.
More Related Videos
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:24Nephrotic Syndrome I : Introduction
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications