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Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
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d-Mannose: Properties, Production, and Applications: An Overview.

Xing Hu1,2, Yaning Shi1,3, Peng Zhang1,2

  • 1State Key Laboratory of Food Science and Technology, Jiangnan Univ, 1800 Lihu Ave, Wuxi, Jiangsu, 214122, P.R. China.

Comprehensive Reviews in Food Science and Food Safety
|January 6, 2021
PubMed
Summary

d-Mannose, a natural monosaccharide, is reviewed for its sources, production, and applications. This glyconutrient is vital in food, pharmaceuticals, and animal feed industries due to its unique structure and function.

Keywords:
applicationsbioprocessingcharacteristicsd-mannosefunctionality

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Area of Science:

  • Biochemistry and Glycoscience
  • Natural Product Chemistry
  • Industrial Biotechnology

Background:

  • d-Mannose is a naturally occurring monosaccharide, structurally a C-2 epimer of d-glucose.
  • It is found in various plants and microorganisms, serving as a key component in polysaccharides and glycoproteins.

Purpose of the Study:

  • To present a comprehensive review of current scientific literature on d-Mannose.
  • To cover its diverse sources, chemical and biological characteristics, production methods, and industrial applications.

Main Methods:

  • Literature review of existing studies on d-Mannose.
  • Analysis of chemical synthesis and biotransformation pathways using enzymes like d-mannose isomerases.

Main Results:

  • d-Mannose can be synthesized chemically or biotransformed from d-fructose or d-glucose.
  • It is extensively utilized in the food, pharmaceutical, and poultry sectors.
  • Applications include dietary supplements, drug synthesis precursors, and animal feed additives for colonization control.

Conclusions:

  • d-Mannose is a glyconutrient with significant research value due to its biological structure and function.
  • Its versatile applications highlight its importance across multiple industries.