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NaYbF4@NaYF4 Nanoparticles: Controlled Shell Growth and Shape-Dependent Cellular Uptake.

Bing Chen1,2, Yuan Wang3, Yang Guo1,2

  • 1Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon 999077, Hong Kong SAR, China.

ACS Applied Materials & Interfaces
|January 6, 2021
PubMed
Summary
This summary is machine-generated.

This study synthesized tunable NaYbF4@NaYF4 core-shell nanoparticles using hot-injection. Quasi-sphere shapes showed superior cellular uptake and DNA delivery, highlighting morphology-dependent properties for nanomedicine applications.

Keywords:
anisotropic straincellular uptakeepitaxial growthsurface modificationupconversion

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Upconversion nanoparticles (UCNPs) are crucial for bioimaging and therapy.
  • Controlling UCNP morphology is key to optimizing their performance.
  • Developing efficient nanocarriers for DNA delivery remains a significant challenge.

Purpose of the Study:

  • To achieve controlled synthesis of NaYbF4@NaYF4 core-shell UCNPs with tunable morphologies.
  • To investigate the influence of synthesis parameters on shell growth and nanoparticle shape.
  • To evaluate the cellular uptake and DNA delivery efficiency of different UCNP morphologies.

Main Methods:

  • Hot-injection technique for synthesizing NaYbF4@NaYF4 core-shell nanoparticles.
  • Controlled addition of acetate or trifluoroacetate precursors to tune shell morphology (long-rod, short-rod, quasi-sphere).
  • DNA modification of nanoparticles followed by incubation with human alveolar basal epithelial cells.
  • Characterization using flow cytometry and confocal microscopy.

Main Results:

  • Successfully synthesized NaYbF4@NaYF4 core-shell UCNPs with controllable morphologies.
  • Identified anisotropic interfacial strain as a factor in anisotropic shell growth, which can be overcome by rapid precursor injection for isotropic growth.
  • Demonstrated superior cellular uptake and DNA delivery efficiency for quasi-sphere shaped nanoparticles.
  • Observed that high dispersibility and ease of membrane wrapping contribute to the favorable performance of quasi-sphere UCNPs.

Conclusions:

  • The hot-injection method allows for controlled synthesis of NaYbF4@NaYF4 core-shell UCNPs with diverse morphologies.
  • Nanoparticle shape significantly impacts cellular uptake and DNA delivery efficacy.
  • Quasi-sphere UCNPs show promise as efficient nanocarriers for biomedical applications.
  • The synthetic strategy can be adapted for other functional nanostructures with morphology-dependent properties.