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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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Interactions between gut microbiota and skeletal muscle.

Florence Gizard1, Anne Fernandez1, Filipe De Vadder2

  • 1Mammalian Cell Biology Group, Institute of Human Genetics UMR9002, CNRS-University of Montpellier, Montpellier, France.

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The gut microbiota significantly impacts host health, influencing nutrition, metabolism, and immunity. Imbalances are linked to diseases, but interventions targeting gut microbes and muscle activity offer therapeutic potential.

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Area of Science:

  • Microbiology
  • Human Physiology
  • Nutrition Science

Background:

  • The gut microbiota plays a crucial role in host nutrition, metabolism, immunity, and neurological functions.
  • Gut dysbiosis is associated with undernutrition, stunting, inflammatory diseases, metabolic disorders, and cancers.
  • Skeletal muscle is integral to interorgan communication, regulating metabolism, immunity, and overall health.

Purpose of the Study:

  • To review the bidirectional relationship between gut microbiota and skeletal muscle.
  • To explore their influence on juvenile growth, physical performance, aging, and chronic diseases.
  • To highlight therapeutic strategies emerging from this interaction.

Main Methods:

  • Literature review of existing research on gut microbiota and skeletal muscle.
  • Analysis of pathways connecting gut microbiota and skeletal muscle, including vascular and organ-specific routes (liver, adipose tissue).
  • Synthesis of findings related to health, fitness, and disease.

Main Results:

  • The gut microbiota and skeletal muscle engage in complex crosstalk affecting host physiology.
  • This interaction influences key life stages and health conditions, from juvenile growth to aging and chronic diseases.
  • Interventions modulating gut microbiota and muscle activity show health benefits.

Conclusions:

  • The gut microbiota and skeletal muscle are critical interconnected components of host health.
  • Understanding their reciprocal influence opens avenues for novel therapeutic approaches.
  • Multimodal strategies combining gut microbiota modulation and physical activity are promising for health and disease management.