Idiopathic CSF pleocytosis in relapsing polychondritis
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Neurology
|February 1, 1988
Abstract:
The association of relapsing polychondritis with CSF pleocytosis is reported for the first time. Three cases are described in which infectious etiologies of the pleocytosis were excluded by appropriate cultures and serologic studies. We suggest that the finding of CSF pleocytosis in relapsing polychondritis does not merit empiric antimicrobial therapy in the absence of demonstrated infection.
Insights
Relapsing polychondritis can cause cerebrospinal fluid (CSF) pleocytosis, a condition typically indicating infection. This study identifies this association, suggesting it doesn't require antibiotics if infection is ruled out.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Relapsing polychondritis is a rare systemic autoimmune disease affecting cartilage.
- Cerebrospinal fluid (CSF) pleocytosis is an increase in white blood cells in the CSF, often indicative of infection.
Observation:
- This study reports three cases of relapsing polychondritis presenting with CSF pleocytosis.
- Infectious causes for the pleocytosis were systematically excluded through cultures and serological tests.
Findings:
- The association between relapsing polychondritis and CSF pleocytosis is described for the first time.
- CSF pleocytosis in the absence of infection is a potential finding in relapsing polychondritis.
Implications:
- Empirical antimicrobial therapy is not warranted for CSF pleocytosis in relapsing polychondritis patients if infection is not demonstrated.
- This finding may alter diagnostic and treatment approaches for patients with relapsing polychondritis and neurological symptoms.