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Idiopathic CSF pleocytosis in relapsing polychondritis
Neurology
|February 1, 1988
Summary
Relapsing polychondritis can cause cerebrospinal fluid (CSF) pleocytosis, a condition typically indicating infection. This study identifies this association, suggesting it doesn't require antibiotics if infection is ruled out.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Relapsing polychondritis is a rare systemic autoimmune disease affecting cartilage.
- Cerebrospinal fluid (CSF) pleocytosis is an increase in white blood cells in the CSF, often indicative of infection.
Observation:
- This study reports three cases of relapsing polychondritis presenting with CSF pleocytosis.
- Infectious causes for the pleocytosis were systematically excluded through cultures and serological tests.
Findings:
- The association between relapsing polychondritis and CSF pleocytosis is described for the first time.
- CSF pleocytosis in the absence of infection is a potential finding in relapsing polychondritis.
Implications:
- Empirical antimicrobial therapy is not warranted for CSF pleocytosis in relapsing polychondritis patients if infection is not demonstrated.
- This finding may alter diagnostic and treatment approaches for patients with relapsing polychondritis and neurological symptoms.