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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Related Experiment Video

Updated: Nov 22, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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Bariatric Surgery and Osteoporosis.

Julien Paccou1,2, Robert Caiazzo3, Eric Lespessailles4

  • 1Department of Rheumatology, MABLaB ULR 4490, CHU Lille, Univ. Lille, 59000, Lille, France. julien.paccou@chru-lille.fr.

Calcified Tissue International
|January 6, 2021
PubMed
Summary

Bariatric surgery negatively impacts bone health, increasing fracture risk. Sleeve gastrectomy may be preferable to Roux-en-Y gastric bypass for preserving bone density and strength.

Keywords:
Bariatric surgeryFracturesGastric bypassObesityOsteoporosisSleeve gastrectomy

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Area of Science:

  • Endocrinology
  • Orthopedics
  • Metabolic Surgery

Background:

  • Bariatric surgery is linked to adverse skeletal health outcomes, including high-turnover bone loss and impaired bone microarchitecture.
  • Evidence suggests an increased fracture risk following bariatric procedures.

Purpose of the Study:

  • To review the impact of bariatric surgery on skeletal health.
  • To compare the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on bone metabolism and fracture risk.

Main Methods:

  • Literature review of studies examining bone health after bariatric surgery.
  • Analysis of evidence comparing RYGB and SG regarding bone mineral density (BMD), bone turnover markers, and fracture incidence.

Main Results:

  • Bariatric surgery leads to significant bone loss and deterioration of bone microarchitecture and strength.
  • RYGB is associated with greater BMD reduction, increased bone turnover, and higher fracture risk compared to SG.
  • Nutritional factors, mechanical unloading, gut hormones, adipokines, and bone marrow adiposity are implicated in post-bariatric bone loss.

Conclusions:

  • Bariatric surgery poses risks to skeletal health, necessitating careful patient selection and management.
  • SG may be a safer option than RYGB for patients concerned about bone health and fracture risk.
  • Adequate calcium, vitamin D, protein intake, and physical activity are crucial post-surgery; osteoporosis treatments may be considered for affected patients.