Genetic Characteristics of Rotavirus Acute Gastroenteritis Among Hospitalized Children of Odisha in Eastern India

Related Experiment Video

Updated: Nov 22, 2025

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

9.1K

Subal Kumar Pradhan1, Sumanta Panigrahi2, Pooja Sagar Padhi3

  • 1Department of Pediatrics, Sardar Vallabhbhai Patel Post Graduate Institute of Paediatrics (SVPPGIP) and SCB Medical College, Cuttack, Odisha, India. drsubal@rediffmail.com.

Indian Journal of Pediatrics
|January 6, 2021
PubMed

Insights

Rotavirus diarrhea is common in hospitalized children under five, with G3P[8] and G1P[8] genotypes prevalent post-vaccine introduction. Continued surveillance is vital to monitor vaccine impact and evolving rotavirus strains.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Vaccinology

Background:

  • Rotavirus is a leading cause of severe diarrheal disease in young children globally.
  • The introduction of rotavirus vaccine into the Universal Immunization Program (UIP) aimed to reduce disease burden.
  • Understanding circulating strains post-vaccination is crucial for assessing vaccine effectiveness and public health strategies.

Purpose of the Study:

  • To determine the epidemiological patterns of rotavirus diarrhea in hospitalized children under five years of age.
  • To identify and characterize the prevalent rotavirus genotypes following the vaccine's introduction in the UIP.
  • To provide data for ongoing rotavirus vaccine surveillance and policy.

Main Methods:

  • A prospective study was conducted from April 2016 to July 2019.
  • Stool samples from hospitalized children under five with acute gastroenteritis were tested for rotavirus using enzyme immunoassay.
  • Rotavirus strains were genotyped using reverse-transcription polymerase chain reaction (PCR); data analyzed with chi-square tests.

Main Results:

  • Rotavirus diarrhea was detected in 36.4% (715/1963) of tested samples.
  • Peak incidence occurred during winter months (December-February) in children aged 6 months to 2 years.
  • The most common genotypes were G3P[8] (50.34%) and G1P[8] (17.46%).

Conclusions:

  • The high prevalence of rotavirus diarrhea underscores the continued importance of rotavirus vaccination.
  • Observed changes in genotype distribution highlight the need for sustained surveillance to monitor vaccine impact on strain evolution.
  • Ongoing monitoring is essential for detecting new rotavirus genotypes and informing future vaccination strategies.
Abstract

Keywords:
Acute gastroenteritisGenotypeRotavirusUnder five years

More Related Videos

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

9.1K
Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

17.5K

Related Concept Videos

Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
2.0K
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
2.7K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
307