Novel aqueous biphasic system based on ionic liquid for the simultaneous extraction of seven active pharmaceutical...

Nonsteroidal anti-inflammatory drugs and antibiotics are classes of active pharmaceutical ingredients (APIs), which are continuously contaminating the ecosystem through various anthropogenic activities. Because of their pseudo-persistence in the aquatic environment and their potentially chronic effects on aquatic life, it is important to closely monitor their concentrations in the aquatic environment using a sensitive analytical method. Sustainable aqueous biphasic systems (ABSs) composed of ionic liquids and biodegradable organic salt (sodium malate) were proposed. The phase diagrams of the systems were firstly determined, and [N₄₄₄₄]Cl-based ABS was selected for the simultaneous extraction and preconcentration of seven APIs. With the developed ABS, extraction efficiencies of APIs close to 100% were obtained. For the developed method, limits of detection (LODs) of 45, 65, 76, 14, 60, 48, and 51 ng L^-1 were obtained for indomethacin, ibuprofen, diclofenac, naproxen, ketoprofen, flurbiprofen, and chloramphenicol, respectively, providing from 1216- to 1238-fold improvement as compared with the analysis without preconcentration. From an economic and environmental point of view, we can predict the prospects and competitive position of the method developed.