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Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program.

Olivia M Dong^1,2, Jill Bates^1,3, Catherine Chanfreau-Coffinier⁴

¹Durham VA Health Care System, Durham, NC 27705, USA.

Pharmacogenomics

|January 6, 2021

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Summary

The Veterans Affairs (VA) launched the Pharmacogenomic Testing for Veterans (PHASER) program, offering multi-gene pharmacogenomic (PGx) testing to 250,000 veterans. This initiative aims to optimize drug response through large-scale PGx implementation across multiple sites.

Area of Science:

Pharmacogenomics
Clinical Implementation
Healthcare Systems

Background:

The Veterans Affairs (VA) initiated the Pharmacogenomic Testing for Veterans (PHASER) program in 2019, a large-scale clinical program providing multi-gene pharmacogenomic (PGx) testing.
The program targets up to 250,000 veterans across approximately 50 sites, with a phased rollout over five years (2019-2023) to enable iterative quality improvements.

Discussion:

The PHASER program addresses a gap in current resources by focusing on the multisite, remote implementation of panel-based PGx testing.
Iterative program improvements are facilitated through Plan-Do-Study-Act cycles during the staggered site initiation.
The program aims to develop a roadmap for maximizing the uptake and optimizing the use of PGx testing.

Key Insights:

Large-scale implementation of pharmacogenomic testing within a major integrated healthcare system.

Keywords:

Veterans Affairs clinical program pharmacogenetics pharmacogenomics precision medicine veterans

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Phased rollout strategy supports iterative quality improvement and adaptation.

Focus on multisite, remote implementation challenges and solutions for PGx testing.

Outlook:

The PHASER program is expected to provide a scalable model for integrating PGx testing into routine clinical practice.
Development of best practices for maximizing PGx test utilization to enhance patient outcomes.
Potential to significantly improve drug response and reduce adverse events for a large veteran population.