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Development of a Virtual Reality Assessment of Everyday Living Skills

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Development and assessment of CootVR, a virtual reality computer program for model building.

Hamish Todd¹, Paul Emsley²

¹Huawei Research and Development, Cambridge, United Kingdom.

Acta Crystallographica. Section D, Structural Biology

|January 6, 2021

Summary

Researchers developed CootVR, a virtual reality program for building 3D atomic models from biological data. While it significantly speeds up specific tasks, overall performance compared to existing software requires further development.

Keywords:

bioinformatics computational crystallography model building virtual reality visualization

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Area of Science:

Structural biology
Computational biology
Biophysics

Background:

Determining 3D structures of biological macromolecules is crucial for understanding their function.
X-ray crystallography and electron cryo-microscopy generate data requiring 3D atomic model building.
Manual model refinement is a time-consuming bottleneck in structural biology workflows.

Purpose of the Study:

To design and assess CootVR, a virtual reality (VR) prototype for molecular model building.
To evaluate the efficiency of VR-based model building compared to traditional methods.

Main Methods:

Development of CootVR, a VR software for interactive molecular model building.
Comparative timing of CootVR against Coot for a specific model-building task.
Assessment of CootVR performance in a from-scratch model building scenario.

Main Results:

CootVR demonstrated an order-of-magnitude speedup for a specific, targeted model-building task.
Overall, CootVR did not provide a speedup compared to Coot for a complete, from-scratch model build.

Conclusions:

Virtual reality offers potential for accelerating specific aspects of molecular model building.
Further development is needed to optimize CootVR for comprehensive model building tasks and achieve overall speed improvements.