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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

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Beclin1 in psoriasis: an immunohistochemical study.

A S Amer1, R M Samaka2, N H Moftah1

  • 1Dermatology and Venereology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Clinical and Experimental Dermatology
|January 6, 2021
PubMed
Summary

This study found increased Beclin1 expression in psoriatic skin, indicating heightened autophagy. This suggests a link between autophagy and the rapid cell growth characteristic of psoriasis.

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Area of Science:

  • Dermatology
  • Cell Biology
  • Molecular Biology

Background:

  • Abnormal autophagy is implicated in skin disorder pathogenesis.
  • Beclin1 protein is a key regulator of autophagy.

Purpose of the Study:

  • To evaluate Beclin1 expression in lesional and perilesional psoriatic skin.
  • To compare Beclin1 expression in psoriasis patients with healthy controls (HCs).

Main Methods:

  • A case-control study involving 20 psoriasis patients and 20 HCs.
  • Immunohistochemical analysis of Beclin1 in skin biopsies (lesional, perilesional, and normal).

Main Results:

  • Beclin1 expression was detected in all groups.
  • Significant differences in Beclin1 epidermal distribution, intensity, and H-score were observed between psoriasis and HC groups (P < 0.01).
  • Altered Beclin1 expression, intensity, and H-score were noted in the dermal inflammatory infiltrate of psoriatic skin compared to perilesional skin (P < 0.05).

Conclusions:

  • Increased Beclin1 expression in psoriatic skin suggests elevated autophagy, potentially linked to rapid keratinocyte proliferation.
  • Beclin1 showed nucleocytoplasmic localization in psoriatic skin versus cytoplasmic in healthy controls, warranting further investigation.