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[Use of ampicillin trihydrate in transplantation surgery]
Abstract:
Ampicillin trihydrate was used for the treatment of 29 patients with purulent inflammatory processes, such as peritonitis, suppurating operative wound, urinary tract infection after the kidney allotransplantation. The antibacterial activity of ampicillin was preliminarily tested on 517 microbial strains, i.e. staphylococci, streptococci, E. coli, Proteus and Ps. aeruginosa isolated from the surgical patients. The strains of penicillin sensitive staphylococci, streptococci and E. coli were most sensitive to the drug effect, the MIC ranging from 0.03 to 16 gamma/ml. It was shown that the blood retention time of the antibiotic was much more prolonged in the patients with a decreased excretion function of the kidneys. The treatment was performed under control of the clinical, bacteriological and biochemical parameters. The drug was used in a dose of 0.5 g 6--8 times a day for 5 to 15 days. A satisfactory therapeutic effect was registered in 73 per cent of the cases.
Insights
Ampicillin trihydrate effectively treated purulent inflammatory processes in 29 patients, showing significant antibacterial activity against common surgical pathogens. Kidney function impacts ampicillin
Area of Science:
- Pharmacology
- Infectious Diseases
- Nephrology
Background:
- Purulent inflammatory processes pose significant clinical challenges in surgical patients.
- Antibiotic resistance necessitates evaluating effective treatment options like ampicillin trihydrate.
- Kidney function can influence antibiotic pharmacokinetics and treatment outcomes.
Purpose of the Study:
- To evaluate the efficacy of ampicillin trihydrate in treating purulent inflammatory processes.
- To assess the antibacterial spectrum of ampicillin trihydrate against clinically relevant microbial strains.
- To investigate the impact of renal function on ampicillin trihydrate's pharmacokinetic profile.
Main Methods:
- Clinical treatment of 29 patients with purulent infections using ampicillin trihydrate (0.5g 6-8 times/day for 5-15 days).
- In vitro susceptibility testing of 517 microbial strains (Staphylococci, Streptococci, E. coli, Proteus, Ps. aeruginosa) against ampicillin.
- Monitoring of clinical, bacteriological, and biochemical parameters during treatment.
Main Results:
- Ampicillin trihydrate demonstrated significant antibacterial activity, with Minimum Inhibitory Concentrations (MICs) ranging from 0.03 to 16 µg/ml against sensitive Staphylococci, Streptococci, and E. coli.
- A satisfactory therapeutic effect was observed in 73% of treated patients.
- Prolonged antibiotic blood retention was noted in patients with impaired renal excretion function.
Conclusions:
- Ampicillin trihydrate is an effective treatment for various purulent inflammatory conditions, including peritonitis, surgical wound infections, and post-transplant urinary tract infections.
- The drug exhibits potent activity against key Gram-positive and Gram-negative bacteria commonly found in surgical settings.
- Clinical management should consider renal function for optimal ampicillin trihydrate dosing and efficacy, especially in patients with decreased kidney excretion.