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Related Experiment Video

Updated: Nov 22, 2025

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Tubular Microcapsules with Polysaccharide Membranes Based on a Co-axial Microfluidic Chip.

Yanting Liu1, Yuanyuan Yang1, Yajing Shen1,2

  • 1Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR 999077, China.

ACS Biomaterials Science & Engineering
|January 6, 2021
PubMed
Summary

Researchers developed a novel polysaccharide-biomaterial tubular microcapsule using microfluidics and polyelectrolyte complex techniques. This artificial biological tube offers potential for controlled drug delivery and transport applications.

Keywords:
LbL assemblymicrocapsulemicrofluidicstubular structure

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Chemical Engineering

Background:

  • Three-dimensional tubular tissue scaffolds are crucial in biomedical engineering but challenging to construct.
  • Existing techniques face limitations in fabricating complex tubular architectures.

Purpose of the Study:

  • To develop a novel polysaccharide-biomaterial-based tubular microcapsule.
  • To create an artificial biological tube architecture for potential drug delivery applications.

Main Methods:

  • Fabrication using a co-axial flow microfluidic chip and polyelectrolyte complex technique.
  • Creation of coiled calcium alginate hydrogel microfibers as building blocks.
  • Layer-by-layer adsorption of alginate and chitosan to form a multilayer membrane, followed by liquefaction to form the tubular structure.

Main Results:

  • The tubular microcapsule demonstrated selective permeability to different molecular weights of FITC-dextran/bovine serum albumin.
  • The structure allowed for sustainable release of encapsulants in an alkaline environment.
  • Successful fabrication of artificial biological tube architectures was achieved.

Conclusions:

  • The developed tubular microcapsule provides an alternative method for manufacturing artificial biological tubes.
  • This technology holds promise for applications in drug transport and delivery systems.