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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable and Magnetic Responsive Hydrogels with Bioinspired Ordered Structures.

Sandra Araújo-Custódio1,2, Manuel Gomez-Florit1,2, Ana R Tomás1,2

  • 13B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal.

ACS Biomaterials Science & Engineering
|January 6, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces injectable, magnetically responsive hydrogels using aligned cellulose nanocrystal-based nanoparticles. These biomaterials promote directional cell growth, offering new possibilities for anisotropic tissue regeneration.

Keywords:
anisotropic hydrogelsmagnetic alignmentmagnetic nanoparticlesordered tissues

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Injectable hydrogels are crucial for minimally invasive regenerative medicine.
  • Isotropic microstructures in conventional hydrogels hinder the regeneration of ordered tissues.

Purpose of the Study:

  • To develop injectable, magnetically responsive nanocomposite hydrogels with directional microstructures.
  • To investigate the potential of these hydrogels for anisotropic tissue regeneration.

Main Methods:

  • Decorating cellulose nanocrystals with magnetic nanoparticles and polymer brushes.
  • Incorporating these nanoparticles into gelatin hydrogels.
  • Aligning nanoparticles using a uniform low magnetic field (108 mT).
  • Evaluating cytocompatibility and cell growth using human stem cells.

Main Results:

  • Achieved injectable, magnetically responsive nanocomposite hydrogels.
  • Demonstrated nanoparticle alignment under magnetic fields, creating anisotropic mechanical properties.
  • Confirmed high cell viability, indicating non-cytotoxicity.
  • Observed directional cell growth induced by the aligned microstructures.

Conclusions:

  • The developed nanocomposite hydrogels offer a tunable platform for creating anisotropic biomaterials.
  • The magnetically induced microstructural patterns guide cell growth, showing promise for regenerating anisotropic tissues.
  • This injectable system has potential for both cellular and acellular regenerative strategies.