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Published on: July 3, 2015
Antioxidant Nanomedicine Protects against Ionizing Radiation-Induced Life-Shortening in C57BL/6J Mice
Chitho P Feliciano1,2, Yukio Nagasaki1,3,4
1Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan.
Abstract:
This study examined a new redox nanoparticle (RNPN) for its ability to protect mice from the life-shortening effect of radiation. A single dose of RNPN was injected subcutaneously into mice 3 or 24 h before whole-body irradiation. Kaplan-Meier survival analysis showed that RNPN given 24 h before whole-body irradiation protected mice against radiation-induced mortality. Histological evaluation of the bone marrow showed that the probable cause of sporadic deaths was bone marrow aplasia. Furthermore, analysis of blood biomarkers revealed abnormalities in the irradiated control group. Such symptoms/indicators of poor health were reduced in RNPN-treated mice.
