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Updated: Nov 22, 2025
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Methylene Blue Loaded Cu-Tryptone Complex Nanoparticles: A New Glutathione-Reduced Enhanced Photodynamic Therapy
Yudi Ruan1,2, Xiaodan Jia1, Chao Wang1,3
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, No. 5625, Renmin Street, Changchun 130022, Jilin, China.
Abstract:
The concentration of intracellular reactive oxygen species directly determines the effect of photodynamic therapy. Reducing intracellular glutathione (GSH) content can increase reactive oxygen species (ROS) level. Therefore, it is extremely important to construct a nanoplatform that can promote photodynamic therapy by consuming GSH. In this study, we synthesized Cu-typtone complex nanoparticles (Cu-Try NPs) by a simple green method and demonstrated their ability to consume GSH to increase intracellular ROS for the first time. Photosensitizer methylene blue was loaded onto Cu-Try NPs (Cu-Try/MB NPs) for enhanced photodynamic therapy. Studies in vitro and in vivo illustrated that enhanced photodynamic therapy based on Cu-Try/MB NPs can kill cancer cells effectively.
