Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineered Extraocular Muscle with Decellularized Tissue and Synthetic Biodegradable Polymers: Design, Properties, and <i>In Vivo</i> Studies.

ACS biomaterials science & engineering·2025
Same author

Fabrication of anodic and atomic layer deposition-alumina coated titanium implants for effective osteointegration applications.

Journal of biomedical materials research. Part A·2024
Same author

Versatile cell cultivation on injectable poly(butylene adipate-co-terephthalate) microcarriers: Impact of surface properties across different cell types.

Journal of biomedical materials research. Part B, Applied biomaterials·2024
Same author

Bioinspired Collagen/Gelatin Nanopillared Films as a Potential Implant Coating Material.

ACS applied bio materials·2022
Same author

UiO-66 metal-organic framework as a double actor in chitosan scaffolds: Antibiotic carrier and osteogenesis promoter.

Biomaterials advances·2022
Same author

Patients- and tissue-specific bio-inks with photoactivated PRP and methacrylated gelatin for the fabrication of osteochondral constructs.

Materials science & engineering. C, Materials for biological applications·2021

Related Experiment Video

Updated: Nov 22, 2025

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.2K

Highly Methacrylated Gelatin Bioink for Bone Tissue Engineering.

Gülseren Irmak, Tuǧrul Tolga Demirtaş, Menemşe Gümüşderelioǧlu

    ACS Biomaterials Science & Engineering
    |January 6, 2021
    PubMed
    Summary

    Microwave-assisted synthesis rapidly produces methacrylated gelatin (Gel-MA) with high methacrylation. This optimized Gel-MA biomaterial enhances 3D bioprinting and promotes osteogenic cell differentiation.

    Keywords:
    bioprintingbone tissue engineeringmethacrylated gelatin (Gel-MA)microwave energy

    More Related Videos

    Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks
    10:25

    Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks

    Published on: December 21, 2019

    19.4K
    Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
    10:36

    Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

    Published on: December 9, 2022

    7.6K

    Related Experiment Videos

    Last Updated: Nov 22, 2025

    Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
    10:19

    Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

    Published on: August 8, 2022

    2.2K
    Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks
    10:25

    Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks

    Published on: December 21, 2019

    19.4K
    Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
    10:36

    Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

    Published on: December 9, 2022

    7.6K

    Area of Science:

    • Biomaterials Science
    • Biotechnology
    • Tissue Engineering

    Background:

    • Methacrylated gelatin (Gel-MA) is a crucial biomaterial for 3D bioprinting.
    • Current Gel-MA synthesis methods require optimization for efficacy and speed.

    Purpose of the Study:

    • To develop a faster and more effective method for synthesizing Gel-MA.
    • To evaluate the properties and biological performance of microwave-assisted synthesized Gel-MA.

    Main Methods:

    • Utilized microwave energy (1000 W) for rapid Gel-MA synthesis.
    • Characterized Gel-MA degree of methacrylation (DM) and rheological properties.
    • Assessed hydrogel mechanical strength, degradation, and bioink viscosity.
    • Evaluated cell viability, proliferation, and osteogenic differentiation of MC3T3-E1 cells.

    Main Results:

    • Achieved ≥90% DM with significantly reduced synthesis time (5 min).
    • Microwave-assisted Gel-MA hydrogels exhibited enhanced elasticity, strength, and slower degradation.
    • Gel-MA bioink viscosity was suitable for 3D bioprinting.
    • Demonstrated superior cell viability, attachment, proliferation, and osteogenic activity in microwave-assisted Gel-MA hydrogels.

    Conclusions:

    • Microwave-assisted synthesis offers a rapid, efficient, and controllable method for producing high-quality Gel-MA.
    • The resulting Gel-MA biomaterial significantly improves osteogenic differentiation of preosteoblastic cells.
    • This optimized Gel-MA is highly promising for advanced bioprinting and regenerative medicine applications.