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Engineered Tissue Development in Biofabricated 3D Geometrical Confinement-A Review
1Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, New York 14260, United States.
ACS Biomaterials Science & Engineering
|January 6, 2021
Summary
Biofabrication technologies create 3D geometrical patterns that guide cell-extracellular matrix interactions, forming engineered tissues. These patterned microenvironments promote the development of biomimetic tissue structures.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Cell Biology
Background:
- Living tissues possess complex structures with cells interacting with extracellular matrices (ECMs) via biochemical and mechanical signals.
- These signals are crucial for tissue formation, homeostasis, and function.
- Engineered tissues aim to mimic native tissue structure and function.
Purpose of the Study:
- To review advanced biofabrication technologies for creating geometrical confinements.
- To explore how these confinements guide cell-ECM interactions and tissue development.
- To highlight the role of geometrical cues in forming biomimetic engineered tissues.
Main Methods:
- Review of lithography-based microfabrication techniques.
- Review of bioprinting technologies.
- Analysis of various geometrical confinement types (microgrooves, microwells, etc.).
Main Results:
- Biofabrication enables the creation of 3D geometrical patterns like microgrooves and micropillars.
- These patterns guide the formation and maturation of various engineered tissues (muscle, epithelial, etc.).
- Geometrical confinements act as vital microenvironmental cues for biomimetic tissue formation.
Conclusions:
- Advanced biofabrication technologies are key to creating controlled microenvironments for tissue engineering.
- Geometrical confinements effectively guide cell behavior and tissue development.
- This approach holds significant potential for recapitulating native tissue structures and functions in engineered constructs.
