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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Polymeric Materials for Eye Surface and Intraocular Applications.

Metin Karayilan1, Liane Clamen2, Matthew L Becker1,3

  • 1Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.

Biomacromolecules
|January 6, 2021
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Summary
This summary is machine-generated.

Polymeric materials offer advanced solutions for eye care, from vision correction contact lenses to implants for damaged eye parts. This review explores their evolution and future potential in ocular applications.

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Area of Science:

  • Ophthalmic biomaterials
  • Polymer science
  • Medical device engineering

Background:

  • The human eye requires timely treatment for injuries, infections, and age-related vision loss.
  • Polymeric materials present innovative solutions for restoring vision and eye function.
  • Advancements in polymer science enable the development of advanced ocular prosthetics and devices.

Purpose of the Study:

  • To review the evolution of polymeric materials in ocular applications.
  • To highlight state-of-the-art polymeric systems for various eye parts.
  • To discuss current limitations and future directions in ocular polymer technology.

Main Methods:

  • Literature review of polymeric materials for ocular applications.
  • Organization of the review following light's path through the eye: contact lenses, cornea, sclera, intraocular lens, and vitreous body.
  • Discussion of synthetic polymers and biopolymers for ocular use.

Main Results:

  • Polymeric materials are crucial for intraocular lenses, contact lenses, corneal/scleral implants, and vitreous substitutes.
  • Next-generation contact lenses include wearable electronics and sensors.
  • Innovations in solid and injectable intraocular lenses and artificial vitreous bodies are emerging.

Conclusions:

  • Polymeric materials have significantly advanced ocular diagnostics, treatment, and vision improvement.
  • Continued research in polymer science promises further breakthroughs in artificial vision and eye repair.
  • Addressing current limitations will drive the next generation of ocular polymeric devices.