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Updated: Nov 22, 2025

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
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Process Intensification Approach Using Microreactors for Synthesizing Nanomaterials-A Critical Review.

Vikas Hakke1, Shirish Sonawane1, Sambandam Anandan2

  • 1Chemical Engineering Department, National Institute of Technology, Warangal 506004, India.

Nanomaterials (Basel, Switzerland)
|January 7, 2021
PubMed
Summary

Process intensification using microreactors offers advanced nanomaterial synthesis. This review details microreactor design and mechanisms for creating novel nanomaterials with unique properties.

Keywords:
continuous flowmicroreactorsnanoparticlesprocess intensificationsegmented flow

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Nanotechnology

Background:

  • Nanomaterials possess unique properties like high surface-to-volume ratio, density, and strength, enabling diverse applications.
  • Traditional synthesis methods often face limitations in controlling size, morphology, and scalability.
  • Process intensification offers a pathway to overcome these limitations in nanomaterial production.

Purpose of the Study:

  • To review recent advancements in nanomaterial synthesis utilizing process intensification.
  • To explore the design principles and fundamental mechanisms of microreactors for nanomaterial synthesis.
  • To highlight the advantages and disadvantages of microfluidics in nanomaterial production.

Main Methods:

  • Review of literature on microreactor design and fabrication for nanomaterial synthesis.
  • Analysis of fundamental mechanisms governing nanomaterial formation within microfluidic systems.
  • Discussion of continuous and segmented flow operations in microfluidics for gas-liquid reactions.

Main Results:

  • Microreactors enable precise control over reaction parameters, leading to enhanced nanomaterial properties.
  • Process intensification via microfluidics facilitates continuous production and improved scalability.
  • Specific examples demonstrate the successful synthesis of various nanomaterials using microfluidic approaches.

Conclusions:

  • Microfluidics and process intensification represent a powerful combination for advanced nanomaterial synthesis.
  • Further research into microreactor design and optimization can unlock new possibilities in nanotechnology.
  • This approach offers a sustainable and efficient route for producing high-performance nanomaterials.